Therapeutic effects of sertraline on improvement of Ovariectomy-induced decreased spontaneous activity in mice

We have already reported that ovariectomized (OVX) rats reduced the spontaneous activity during dark period due to decease of serotonin release in amygdala. In this study, we examined potential sertraline, a selective reuptake inhibitor, on recovery less seen mice with OVX-induced despair-like behaviors. Female 9-week old ICR were underwent either OVX or sham surgery. Sertraline (10 mg/kg/day, s.c.) saline started administer each group for 8 weeks (6 times/week) from 8th week after OVX. Each mouse was evaluated (19:00-07:00) using an infrared sensor. Moreover, mRNA expression levels tryptophan hydroxylase (TPH) and X-box binding protein 1 (XBP1) measured hippocampus prefrontal cortex by real-time PCR method. found out behaviors improved continuous administration sertraline. After treatment OVX, our data showed sertraline significantly suppressed upregulation XBP1 both cortex, although suppression downregulation TPH only hippocampus. These results suggest improves decrease induced assessed suppressing decreased synthesis serotonergic neuron.